Endocrine Abstracts

Introduction: Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is underdiagnosed and appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents).Objective: To study features of patients with LADA diagnosed and treated in our clinic.Material and methods: Retrospective study of patients attended in our clinic in ...

Background: GH plays an important role in maintaining physiological morphology and function of the left ventricle (LV). In GH deficient (GHD) patients a systolic and/or diastolic LV dysfunction has been documented. LV systolic dysfunction results from reduced LV mass (LVM), which subsequently leads to a decrease of the LV ejection fraction (EF). Results from clinical trials evaluating the effect of GH replacement therapy on the morphological and functional changes of the LV in...

Introduction: Denosumab discontinuation rapidly reverses bone turnover inhibition and eliminates anti-fracture protection. Multiple vertebral fractures (MVF) were reported in this scenario. Previously, we reported a retrospective real-life analysis designed to estimate fracture risk following denosumab discontinuation. Here we report a patient-level data of a subgroup with MVF.Methods: Via computerized database of Maccabi Healthcare Services, persistent ...

Background: The clinical presentation of hyperthyroidism has been studied in the ambulatory caresetting. Our hospital performs a TSH test for all newly admitted patients.Aim: To describe the clinical presentation of patients with overt hyperthyroidism during hospitalization and to study the association between thyroid hormone levels and the clinical picture.Methods: A retrospective study of 250 hospitalized patients from an 11-year...

Introduction: Primary hypoparathyroidism (PH) is a rare condition. After surgery and chronic alcoholism, an autoimmune disease is the most common etiology and must specifically be considered in the context of a patient with other autoimmune endocrine diseases.Case report: MASD a male caucasian patient aged 31, was admitted to the emergency department because of perioral and hand paresthesias, and carpal spasm, in the context of a generalized anxiety reac...

Introduction: Graves’ disease is an autoimmune condition with an estimated prevalence of about 2%, 5–10 times more frequent in females. A multifactorial nature is assumed, with genetic contribution accounting for up to 80% of the variability. Relevant genes includegeneral autoimmune risk loci, such as the HLA region, CTLA-4, PTPN22 and CD40, as well as thyroid-specific loci (thyroglobulin and TSH receptor genes). We report a particular case of Graves’ d...

Introduction: Myxedema coma is a medical emergency and can be associated with respiratory failure. Intubated patients have been known to require persistent efforts in ventilator weaning, with one case reported to take 7 months before success.Case report: A 77-year-old gentleman with known primary hypothyroidism presented with chest infection. He had defaulted thyroxine for the past 6 months, relying instead on complementary health products. Thyroid funct...

Introduction: Generously supported by IPSEN)-->Carbohydrate metabolism (CHM) is impaired in over 30% of acromegalic patients. Natural history of acromegaly and treatment modalities, i.e. surgery, somatostatin analogues (SSA) and pegvisomant, may impact in a different way on CHM.Aim: To assess CHM alterations (impaired fasting glucose (IFG) and diabetes mellitus (DM)) in acromegaly and their relationship with cl...

Data on coexisting Graves’ disease (GD), systemic lupus erythematosus (SLE), and hypoparathyroidism (hypop) are limited. Scanty case reports have described hypoparathyr or hypothyroidism (late complication) following external irradiation to the neck. The thyroid and parathyroid glands may be sensitive to the immunologic or irradiation damage.A 34-year old AA woman presented with tetanic-like cramps, easy skin bruising, fatigue, weight gain, nocturia...

Background and aim: Papillary thyroid carcinomas (PTCs) with a diameter <1 cm are referred to as papillary microcarcinomas (PTMCs). They are being diagnosed with increasing frequency. Within this type of tumour some clinical and histological characteristics with prognostic and therapeutic impact have been proposed. In the present study we describe the clinical and pathological presentation of PTMCs and compare them with papillary thyroid carcinomas of larger size.<p cl...